Adult Umbilical Cord Blood Transplantation Using Myeloablative Total Body Irradiation, Fludarabine, and Thiotepa Conditioning
نویسندگان
چکیده
منابع مشابه
Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen.
Umbilical cord blood transplant recipients are exposed to an increased risk of graft failure, a complication leading to a higher rate of transplant-related mortality. The decision and timing to offer a second transplant after graft failure is challenging. With the aim of addressing this issue, we analyzed engraftment kinetics and outcomes of 1268 patients (73% children) with acute leukemia (64%...
متن کاملReduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies
Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of 8-Gy total body irradiation (TBI), fludarabine (FLU) and cyclophosphamide (CY)...
متن کاملFactors associated with pulmonary toxicity after myeloablative conditioning using fractionated total body irradiation
PURPOSE Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. MATERIALS AND METHODS Fifty-eight patients with hematologic malignancies who underwent TBI before allogene...
متن کاملUmbilical cord blood transplantation
Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disp...
متن کاملUmbilical cord blood transplantation.
Umbilical cord blood transplantation (CBT) has been widely used as an alternative source of hematopoietic cell support for stem cell transplant patients. CBT offers several advantages over traditional stem cell sources, such as immediate availability, absence of risk for donors, lower risk of acute graft-versus-host disease, and a less stringent requirement for human leukocyte antigen matching....
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.3395.3395